Children and ADRs (Adverse Drug Reactions)

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Children and ADRs (Adverse Drug Reactions)

Many medicines are prescribed to the paediatric population on an unlicensed or 'off-label' basis because they have not been adequately tested and/or formulated and authorized for use in appropriate paediatric age groups. Regulatory authorities also need to remind health professionals about the importance of their contribution towards the process of paediatric pharmacovigilance thanks to their r...

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Epidermiology of adverse drug reactions (ADRs) in the elderly

Results A total of 15,541 ADRs was reported in patients greater than or equal to 18 years. Common causative drug category included nervous system, neoplastic, anti-infectives. The prevalence of ADRs due to respiratory drugs and cardiovascular drugs was higher in the elderly group (¡Ã 60 years) than in other groups. The most prevalent clinical types were gastrointestinal disorders and skin and a...

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Pharmacogenomics and adverse drug reactions in children

Adverse drug reactions are a common and important complication of drug therapy in children. Over the past decade it has become increasingly apparent that genetically controlled variations in drug disposition and response are important determinants of adverse events for many important adverse events associated with drug therapy in children. While this research has been difficult to conduct over ...

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Adverse drug reactions in hospitalized Colombian children

INTRODUCTION The occurrence of adverse drug reactions is an important issue due to the lack of drug safety data in children. OBJECTIVE To describe the Adverse Drug Reactions in inpatient children under 6 years of age in two general pediatrics wards located in Barranquilla, Colombia. METHODS A prospective cohort study based on intensive pharmacovigilance was conducted during six months in or...

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A Systematic Investigation of Computation Models for Predicting Adverse Drug Reactions (ADRs)

BACKGROUND Early and accurate identification of adverse drug reactions (ADRs) is critically important for drug development and clinical safety. Computer-aided prediction of ADRs has attracted increasing attention in recent years, and many computational models have been proposed. However, because of the lack of systematic analysis and comparison of the different computational models, there remai...

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ژورنال

عنوان ژورنال: Italian Journal of Pediatrics

سال: 2010

ISSN: 1824-7288

DOI: 10.1186/1824-7288-36-4